This popular large pub is named after a 19th-century railway industry magnate, who was a company director of the world's first public railway, the Stockton & Darlington. The Isaac was a Wetherspoon's conversion of the former law courts and. no doubt, more familiar to some than others, and continues to, more or less, follow the original Wetherspoon's formula. It comprises one long bar serving an eletic range of eleven guests beers to a single room, with walls adorned with photographs of old Middlesbrough. Third pint are glasses available. Pub grub is served all day everyday.

In November 2017, after a short period of closure, new owners took over and continued with, more or less, the same underlying Wetherspoon's formula, but without having the bar adorned with the former owner's national brands.

CAMRA members discount scheme in place to card carrying members.